How really, really awful science is in medicine

First, the Atlantic has a really terrific post on how really, really awful science is in medicine.

80 percent of non-randomized studies (by far the most common type) turn out to be wrong, as do 25 percent of supposedly gold-standard randomized trials, and as much as 10 percent of the platinum-standard large randomized trials.

... He zoomed in on 49 of the most highly regarded research findings in medicine over the previous 13 years... Of the 49 articles, 45 claimed to have uncovered effective interventions. Thirty-four of these claims had been retested, and 14 of these, or 41 percent, had been convincingly shown to be wrong or significantly exaggerated.

... How should we choose among these dueling, high-profile nutritional findings? Ioannidis suggests a simple approach: ignore them all. ...

It goes on and on. Medicine is just not in the least bit scientific. At all. It's really, really sad.